Clinical Trial Simulation

The current situation

Clinical studies are key contributors to the mission of many policy, research, and voluntary health organizations, and because they require a significant investment of an organization’s limited time and resources, it is critical to plan carefully to help ensure a trial’s success.  Studies can fail to support objectives because of underpowering, inability to generalize results (e.g., due to narrow population), and outdated results due to long study duration.

Archimedes can help organizations:

• Estimate sample size more accurately (via better understanding of baseline/control arm event rates)
• Explore different populations, intervention protocols, trial durations, and choices for outcomes
• Increase likelihood of success and sharpen relevance for organization’s objectives
• Preview possible trial outcomes in simulated healthcare systems where patients do not always take medications and physicians to not always follow guidelines

The Archimedes advantage

The Archimedes Model is a comprehensive simulation model built to represent physiological, clinical, and administrative events as they occur in reality. It has been in development since 1993 and more than 50 clinical trials have been used to validate it. The Model can accurately represent populations, protocols, and outcomes at the level of detail used in real clinical trials.