Portfolio Strategy
The current situation
Selection of an early clinical-stage drug candidate for advancement to Phase 2/3/4 clinical trials is a critical decision in the drug development process. Expert opinion is often used to guide portfolio strategy, and while it is a valuable resource, it also has limitations. First, expert opinion is generally qualitative in nature and based on subjective assessments rather than on a quantitative assessment of human physiology, diseases, treatments, or behavior. Second, it has limited value in emerging fields where even experts have little experience.
The Archimedes advantage
The Archimedes Model is a comprehensive, validated simulation model. It combines our best scientific knowledge about human physiology, diseases, behaviors, interventions, and healthcare systems.
The Model can help companies identify and prioritize candidate drugs that will have the greatest chance of success in Phase 2/3/4 trials. It can run simulated clinical trials for a set of pipeline drugs and forecast the effect of these drugs on downstream health outcomes and costs. Combining expert opinion with data from the Archimedes Model provides a robust platform for developing a portfolio strategy.
How you can use the Archimedes Model
ARCHeS Innovator. Using ARCHeS Innovator, our powerful online tool, you can use most of the power of the Archimedes Model directly. ARCHeS Innovator cover conditions, treatments, and outcomes related to coronary artery disease, stroke, diabetes and its complications, obesity, hypertension, dyslipidemia, and smoking. You can create simulations of multiple scenarios involving different assumptions about your products, and the results can be analyzed for different target populations, clinical endpoints, and assumptions. It can also be used to create new or hypothetical treatments, either by drawing on the results of phase 2 clinical trials or by specifying effects on biomarkers and/or health outcomes. More...
Modeling & Consulting Services. For diseases and interventions beyond the scope of ARCHeS Innovator, Archimedes provides comprehensive support to help you run custom simulations. Our team of scientists and physicians will work with you to develop your objectives, forecast the effect of new products on outcomes of interest, analyze and interpret the data, and make concrete portfolio recommendations. More...
