Clinical Trial Simulation
The current situation
Government organizations initiate scores of clinical trials every year. Each trial costs millions, or even hundreds of millions of dollars. The cost of a trial and the applicability of its results depend heavily on the choice of the population, number of participants, definition of outcomes, and duration. Many studies fail to provide actionable information because the sample size is too small or the duration is too short. Others are unnecessarily expensive. By simulating clinical trials before they are executed, Archimedes can help government organizations:
- Explore different populations, intervention protocols, and definitions for outcomes to more accurately estimate the sample size and duration required to find a statistically significant effect
- Avoid potentially costly errors and mitigate risk by reducing the uncertainties in powering a trial
The Archimedes advantage
The Archimedes Model is a comprehensive simulation model built to represent physiological, clinical, and administrative events as they occur in reality. It has been in development since 1993 and more than 50 clinical trials have been used to validate it. The Model can accurately represent populations, protocols, and outcomes at the same level of detail used in real clinical trials.
How you can use the Archimedes Model
ARCHeS Innovator. ARCHeS Innovator is a comprehensive web-based tool that gives you access to the Archimedes Model and enables you to simulate clinical trials relating to cardio-metabolic risk. For each simulation, ARCHeS gives you the power to specify:
- Inclusion and exclusion criteria based on key patient characteristics and biomarkers
- Baseline characteristics for a population
- Treatment for cardio-metabolic conditions including antihypertensive agents, cholesterol treatments, and interventions for obesity and smoking
ARCHeS Innovator can also be used to create new or hypothetical treatments, either by drawing from the results of phase 2 clinical trials or by specifying effects on biomarkers and/or health outcomes. More...
Modeling & Consulting Services. Archimedes provides comprehensive support to help you run custom clinical trial simulations. For questions beyond the scope of ARCHeS Innovator, our team of scientists and physicians can work with you to develop objectives, design simulations to answer the questions of interest, and analyze and interpret the data. More...
